[Slaam] Reminder: SLAAM Seminar Monday, June 12th, 9am Pacific: Patrick McCall (TU Dresden and Max Planck CBG)

[SLAAM Distribution List]

Dear enthusiasts of the SLAAM seminars,


This is a gentle reminder that today's Soft Living Active and Adaptive Matter (SLAAM)<https://physics.ucmerced.edu/slaam> seminar will be given by Dr. Patrick McCall  (TU Dresden and Max Planck Institute) starting at 9am Pacific (11am Central US/12 noon Eastern time (US)/1800 Central European/9:30 pm India/12 am China), Monday, June 12th,  with the title:



“Contrasting phases: insights into the physical properties of biomolecular condensates”



Please join at the link below to attend:

https://ucmerced.zoom.us/j/92693607475?pwd=TnI5dDhRRnYvejNZK2xNN0s4M0R5UT09

Zoom Meeting ID: 926 9360 7475   |   Passcode: 223642



Please see more info in the flyer here<https://physics.ucmerced.edu/sites/physics.ucmerced.edu/files/page/documents/patrick_mccall_slaam.pdf> and in the text below:


Abstract

Many compartments within living cells exist as condensed fluid phases demixed from the surrounding solution. These biomolecular condensates are enriched in many distinct proteins and nucleic acids and are thought to provide unique microenvironments for cellular biochemistry. Although the molecular composition of these multi-component condensates is crucial to their identity and physical properties, challenges in composition measurement have largely precluded establishment of a quantitative physical picture for these phases. In this talk, I’ll describe our development of a label-free method based on quantitative (optical) phase microscopy to efficiently and precisely measure the composition and shape of micron-sized reconstituted biomolecular condensates. In addition to dynamic and temperature-dependent measurements in binary systems, I will present a general procedure to measure composition in multi-component condensates, which we validate by measuring the tie-lines and binodals for a ternary mixture containing RNA and the full-length RNA-binding protein FUS. Finally, I will discuss implications of our composition measurements for other physical properties of condensates (e.g. mechanical, dielectric, surface), and speculate on potential biological consequences of property modulation.


About the speaker:
Patrick is a postdoctoral researcher working jointly with Jan Brugués in the Excellence Cluster: Physics of Life at TU Dresden and Tony Hyman at the Max Planck Institute of Molecular Cell Biology and Genetics. By combining biochemical reconstitution with light microscopy and tools from soft matter physics, his research seeks to illuminate the molecular basis and physical properties of self-organized sub-cellular structures, such as biomolecular condensates. He earned his PhD in Physics from the University of Chicago in 2017 advised by Margaret Gardel, where he studied the influence of non-equilibrium activity on the mechanics and dynamics of actin-based structures.

Hope to see you there!
Best regards,
Kinjal Dasbiswas

on behalf of the SLAAM organizing team
(Alexandra Tayar, Suraj Shankar, Daniel Beller, Kinjal Dasbiswas)

To join the SLAAM mailing list, please sign up  here<https://urldefense.proofpoint.com/v2/url?u=https-3A__docs.google.com_forms_d_e_1FAIpQLScTyzEuuE7TfrrapgP4tzN-5FoPSqbBhURUxa9-2Dzc8USnY1IPzA_viewform&d=DwMFAw&c=WO-RGvefibhHBZq3fL85hQ&r=6T170XR90Za4-nl9r1e8-WfEJbvH5g5hJbA9UumqfWQ&m=NK4EGo1VvrDiYSxdvOUJXgCkEAzTrQzNpQi-P59LZiKL_lMA3briJm9KQh9Y3suN&s=3hc1lEhiJwBLtMEr12Z9K5XtZaVlEfOZKYXGtXCjRDg&e=>. If you’re a postdoc interested in giving a SLAAM talk, we invite you to register your interest on that webform.






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