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<span class="x_x_contentpasted0" style="margin:0px"><span class="x_ContentPasted0" style="font-size: 12pt; margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black;">Dear enthusiasts of the SLAAM seminars,<br>
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<span class="x_x_contentpasted0" style="margin: 0px;"><span class="x_ContentPasted0" style="font-size: 12pt; margin: 0px;"><font style="color: rgb(36, 36, 36);">This is a gentle reminder that today's </font></span></span><a href="https://physics.ucmerced.edu/slaam" data-auth="NotApplicable" title="https://physics.ucmerced.edu/slaam" data-linkindex="0" class="x_ContentPasted0" data-loopstyle="linkonly" style="font-size: 12pt; color: rgb(5, 99, 193);">Soft
Living Active and Adaptive Matter (SLAAM)</a><span style="font-size: 12pt; color: black;"> seminar will be given by </span><b class="x_ContentPasted0" style="font-family: inherit; font-size: 12pt; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; color: black;">Dr. Patrick
McCall <span class="x_ContentPasted0"> </span></b><span style="font-size: 12pt; color: black;">(TU Dresden and Max Planck Institute) starting </span><b class="x_ContentPasted0" style="font-family: inherit; font-size: 12pt; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; color: black;"></b><span style="font-size: 12pt; color: black;">at </span><b class="x_ContentPasted0" style="font-family: inherit; font-size: 12pt; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; color: black;">9am
Pacific (</b><span class="x_ContentPasted0" style="font-size: 12pt; color: black;">11am Central US/12 noon Eastern time (US)/1800 Central European/9:30 pm India/12 am China), <b class="x_ContentPasted0 ContentPasted0" style="font-size: 12pt; color: black;">Monday, June
12th, </b></span><b class="x_ContentPasted0" style="font-family: inherit; font-size: 12pt; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; color: black;"> </b><span style="font-size: 12pt; color: black;">with the title:</span></p>
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<b><span class="x_ContentPasted0" style="font-size:12pt; margin:0px">“Contrasting phases: insights into the physical properties of biomolecular condensates”</span></b></p>
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<span class="x_x_contentpasted0" style="margin:0px"><span class="x_ContentPasted0" style="font-size: 12pt; margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black;">Please join at the link below to attend:</span></span><span style="font-size:12pt; margin:0px"></span></p>
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<span style="font-size: 12pt; margin: 0px; color: black;"><a href="https://ucmerced.zoom.us/j/92693607475?pwd=TnI5dDhRRnYvejNZK2xNN0s4M0R5UT09" data-auth="NotApplicable" title="https://ucmerced.zoom.us/j/92693607475?pwd=TnI5dDhRRnYvejNZK2xNN0s4M0R5UT09" data-linkindex="1" class="x_ContentPasted0" style="margin: 0px; text-decoration: underline; color: rgb(5, 99, 193);"><span style="margin:0px; font-family:Calibri,Helvetica,sans-serif">https://ucmerced.zoom.us/j/92693607475?pwd=TnI5dDhRRnYvejNZK2xNN0s4M0R5UT09</span></a></span><span style="font-size:12pt; margin:0px"></span></p>
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<span class="x_x_contentpasted0" style="margin:0px"><span class="x_ContentPasted0" style="font-size: 12pt; margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black;">Zoom Meeting ID: 926 9360 7475 | Passcode: 223642</span></span><span style="font-size:12pt; margin:0px"></span></p>
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<span class="x_ContentPasted0" style="font-size:12pt; margin:0px; font-family:Calibri,Helvetica,sans-serif">Please see more info in the flyer </span><span class="x_ContentPasted0" style="font-size:12pt; margin:0px"><a href="https://physics.ucmerced.edu/sites/physics.ucmerced.edu/files/page/documents/patrick_mccall_slaam.pdf" data-auth="NotApplicable" title="https://physics.ucmerced.edu/sites/physics.ucmerced.edu/files/page/documents/patrick_mccall_slaam.pdf" data-loopstyle="linkonly" id="LPlnk417537">here</a><span class="x_x_apple-converted-space x_ContentPasted0" style="margin:0px; font-family:Calibri,Helvetica,sans-serif"> </span></span><span class="x_ContentPasted0" style="font-size:12pt; margin:0px; font-family:Calibri,Helvetica,sans-serif">and
in the text below</span><span class="x_ContentPasted0" style="font-size:12pt; margin:0px">:</span></p>
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<span class="x_ContentPasted0 x_ContentPasted1" style="font-size:12pt; margin:0px; font-family:Calibri,Helvetica,sans-serif"><b>Abstract</b></span></p>
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<span class="x_ContentPasted0 x_ContentPasted1" style="font-size:12pt; margin:0px; font-family:Calibri,Helvetica,sans-serif">Many compartments within living cells exist as condensed fluid phases demixed from the surrounding solution. These biomolecular condensates
are enriched in many distinct proteins and nucleic acids and are thought to provide unique microenvironments for cellular biochemistry. Although the molecular composition of these multi-component condensates is crucial to their identity and physical properties,
challenges in composition measurement have largely precluded establishment of a quantitative physical picture for these phases. In this talk, I’ll describe our development of a label-free method based on quantitative (optical) phase microscopy to efficiently
and precisely measure the composition and shape of micron-sized reconstituted biomolecular condensates. In addition to dynamic and temperature-dependent measurements in binary systems, I will present a general procedure to measure composition in multi-component
condensates, which we validate by measuring the tie-lines and binodals for a ternary mixture containing RNA and the full-length RNA-binding protein FUS. Finally, I will discuss implications of our composition measurements for other physical properties of condensates
(e.g. mechanical, dielectric, surface), and speculate on potential biological consequences of property modulation.</span></p>
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<div class="x_ContentPasted1" style="color: rgb(0, 0, 0);"><span style="font-family:Calibri,Helvetica,sans-serif"><b>About the speaker:</b></span></div>
<div style="color: rgb(0, 0, 0);"><span style="font-family:Calibri,Helvetica,sans-serif; font-size:12pt">Patrick is a postdoctoral researcher working jointly with Jan Brugués in the Excellence Cluster: Physics of Life at TU Dresden and Tony Hyman at the Max
Planck Institute of Molecular Cell Biology and Genetics. By combining biochemical reconstitution with light microscopy and tools from soft matter physics, his research seeks to illuminate the molecular basis and physical properties of self-organized sub-cellular
structures, such as biomolecular condensates. He earned his PhD in Physics from the University of Chicago in 2017 advised by Margaret Gardel, where he studied the influence of non-equilibrium activity on the mechanics and dynamics of actin-based structures.</span><br>
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<div style="color: rgb(0, 0, 0);"><span style="font-family:Calibri,Helvetica,sans-serif; font-size:12pt">Hope to see you there!</span></div>
<div style="color: rgb(0, 0, 0);"><span class="x_ContentPasted2" style="font-family:Calibri,Helvetica,sans-serif; font-size:12pt">Best regards,
<div>Kinjal Dasbiswas</div>
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<div class="x_ContentPasted2">on behalf of the SLAAM organizing team</div>
<div class="x_ContentPasted2">(Alexandra Tayar, Suraj Shankar, Daniel Beller, Kinjal Dasbiswas)</div>
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To join the SLAAM mailing list, please sign up <a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__docs.google.com_forms_d_e_1FAIpQLScTyzEuuE7TfrrapgP4tzN-5FoPSqbBhURUxa9-2Dzc8USnY1IPzA_viewform&d=DwMFAw&c=WO-RGvefibhHBZq3fL85hQ&r=6T170XR90Za4-nl9r1e8-WfEJbvH5g5hJbA9UumqfWQ&m=NK4EGo1VvrDiYSxdvOUJXgCkEAzTrQzNpQi-P59LZiKL_lMA3briJm9KQh9Y3suN&s=3hc1lEhiJwBLtMEr12Z9K5XtZaVlEfOZKYXGtXCjRDg&e=" data-auth="NotApplicable" title="https://urldefense.proofpoint.com/v2/url?u=https-3A__docs.google.com_forms_d_e_1FAIpQLScTyzEuuE7TfrrapgP4tzN-5FoPSqbBhURUxa9-2Dzc8USnY1IPzA_viewform&d=DwMFAw&c=WO-RGvefibhHBZq3fL85hQ&r=6T170XR90Za4-nl9r1e8-WfEJbvH5g5hJbA9UumqfWQ&m=NK4EGo1VvrDiYSxdvOUJXgCkEAzTrQzNpQi-P59LZiKL_lMA3briJm9KQh9Y3suN&s=3hc1lEhiJwBLtMEr12Z9K5XtZaVlEfOZKYXGtXCjRDg&e=" data-loopstyle="linkonly" id="LPNoLPOWALinkPreview">
here</a>. If you’re a postdoc interested in giving a SLAAM talk, we invite you to register your interest on that webform.<br>
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