[QSB-grads] Fwd: Professor Glenn Millhauser (UC Santa Cruz) seminar on May 18th (BioEngineering Seminar Series, Spring 2018)

[Miriam Barlow]

Professor Glenn Millhauser from the Chemistry and Biochemistry Department
of UC Santa Cruz will be a speaker for the BioEngineering Department
Seminar Series. He will visit our campus on May 18th. The seminar will take
place in Student Services Building (SSB), Room 120 from 11am to 12:15pm
with the title shown below. Please, find attached a tentative schedule for
his visit and let me know whether you will be interested in meeting with
Professor Millhauser.

Regards,

Eva de Alba

--------------------------------------------------------

Seminar Title:

"How Metal Ions in the Brain Tip the Toxic Balance of the Killer Prion
Protein"

Glenn L. Millhauser

Chemistry and Biochemistry, UC Santa Cruz

A *prion* is a misfolded form of the cellular prion protein, PrPC.
Although the role of PrP in neurodegeneration was established over 30 years
ago, there is little understanding of the protein’s normal function, and
how misfolding leads to profound disease.  Recent work shows that PrPC
coordinates Cu2+ and Zn2+ cofactors, and regulates the distribution of
these essential metal ions in the brain.  Moreover, these metals stabilize
a previously unseen fold in PrPC, the observation of which provides new
insight into the mechanism of prion disease, and perhaps other
neurodegenerative diseases.  I will provide a brief background on prion
diseases and discuss physiology and magnetic resonance experiments that
reveal a new PrPC fold feature promoted by metal ions.

*______________________________________*
*EVA DE ALBA, PhD*
Acting Associate Professor
School of Engineering
Bioengineering Unit
*UNIVERSITY OF CALIFORNIA, MERCED*
Bldg. S&E2. Rm. 382.
<pbrown3 at ucmerced.edu>
5200 North Lake Road, Merced, CA 95343

* _______________________________________ *




-- 
Miriam Barlow
Founding Faculty and Associate Professor
Chair, Quantitative and Systems Biology
University of California, Merced

209.228.4174
miriam.barlow at gmail.com
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