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 Biochemistry Department of UC Santa Cruz will be a speaker for the BioEngineering Department Seminar Series. He will visit our campus on May 18th. The seminar will take place in Student Services Building (SSB), Room 120 from 11am to 12:15pm with the title
 shown below. Please, find attached a tentative schedule for his visit and let me know whether you will be interested in meeting with Professor Millhauser.</font></div>
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<div style="margin-top:0;margin-bottom:0">Regards,</div>
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<div style="margin-top:0;margin-bottom:0">Eva de Alba</div>
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<div style="margin-top:0;margin-bottom:0">Seminar Title:<br>
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<div style="margin:0"><font size="3" face="Arial"><span style="font-size:12pt">"How Metal Ions in the Brain Tip the Toxic Balance of the Killer Prion Protein"</span></font></div>
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<div style="margin:0"><font size="3" face="Arial"><span style="font-size:12pt">Glenn L. Millhauser</span></font></div>
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<div style="margin:0"><font size="3" face="Arial"><span style="font-size:12pt">Chemistry and Biochemistry, UC Santa Cruz</span></font></div>
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<div style="margin:0"><font size="3" face="Arial"><span style="font-size:12pt">A
<i>prion</i> is a misfolded form of the cellular prion protein, PrP<font size="-1">^C</font>.  Although the role of PrP in neurodegeneration was established over 30 years ago, there is little understanding of the protein’s normal function, and how
 misfolding leads to profound disease.  Recent work shows that PrP<font size="-1">^C</font> coordinates Cu<font size="-1">²⁺</font> and Zn<font size="-1">²⁺</font> cofactors, and regulates the distribution of these essential
 metal ions in the brain.  Moreover, these metals stabilize a previously unseen fold in PrP<font size="-1">^C</font>, the observation of which provides new insight into the mechanism of prion disease, and perhaps other neurodegenerative diseases. 
 I will provide a brief background on prion diseases and discuss physiology and magnetic resonance experiments that reveal a new PrP<font size="-1">^C</font> fold feature promoted by metal ions.
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<div dir="ltr" style="text-align:left"><font style="font-family:Calibri,sans-serif,serif,"EmojiFont"" size="2" face="Calibri,sans-serif"><span style="font-size:11pt"><font style="font-family:Century Gothic,sans-serif,serif,"EmojiFont"" size="2" color="#DFB917" face="Century Gothic,sans-serif"><span style="font-size:10pt"><u><span style="font-family:"Century Gothic",sans-serif"><font style="font-family:Calibri,sans-serif,serif,"EmojiFont"" size="2" face="Calibri,sans-serif"><span style="font-size:11pt"><font style="font-family:Century Gothic,sans-serif,serif,"EmojiFont"" size="2" color="#DFB917" face="Century Gothic,sans-serif"><span style="font-size:10pt"><u>______________________________<wbr>________</u></span></font><font style="font-family:Century Gothic,sans-serif,serif,"EmojiFont"" size="2" color="#17365D" face="Century Gothic,sans-serif"><span style="font-size:10pt" lang="it"></span></font></span></font></span></u><b><u><span style="font-family:"Century Gothic",sans-serif"><font style="font-family:Calibri,sans-serif,serif,"EmojiFont"" size="2" face="Calibri,sans-serif"><span style="font-size:11pt"><font style="font-family:Century Gothic,sans-serif,serif,"EmojiFont"" size="2" color="#17365D" face="Century Gothic,sans-serif"><span style="font-size:10pt" lang="it"><b><br>
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<div style="margin:0"><font style="font-family:Calibri,sans-serif,serif,"EmojiFont"" size="2" face="Calibri,sans-serif"><span style="font-size:11pt"><font style="font-family:Century Gothic,sans-serif,serif,"EmojiFont"" size="2" color="#17365D" face="Century Gothic,sans-serif"><span style="font-size:10pt" lang="it"><b>EVA
 DE ALBA, PhD</b></span></font></span></font></div>
<div style="margin:0"><font style="font-family:Calibri,sans-serif,serif,"EmojiFont"" size="2" face="Calibri,sans-serif"><span style="font-size:11pt"><font style="font-family:Century Gothic,sans-serif,serif,"EmojiFont"" size="2" color="#376092" face="Century Gothic,sans-serif"><span style="font-size:9pt" lang="it">Acting
 Associate Professor</span></font></span></font></div>
<div style="margin:0"><font style="font-family:Calibri,sans-serif,serif,"EmojiFont"" size="2" face="Calibri,sans-serif"><span style="font-size:11pt"><font style="font-family:Century Gothic,sans-serif,serif,"EmojiFont"" size="2" color="#376092" face="Century Gothic,sans-serif"><span style="font-size:9pt" lang="it">School
 of Engineering<br>
Bioengineering</span></font></span></font><font style="font-family:Calibri,sans-serif,serif,"EmojiFont"" size="2" face="Calibri,sans-serif"><span style="font-size:11pt"><font style="font-family:Century Gothic,sans-serif,serif,"EmojiFont"" size="2" color="#376092" face="Century Gothic,sans-serif"><span style="font-size:9pt" lang="it">
 Unit<br>
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<div style="margin:0"><font style="font-family:Calibri,sans-serif,serif,"EmojiFont"" size="2" face="Calibri,sans-serif"><span style="font-size:11pt"><font style="font-family:Century Gothic,sans-serif,serif,"EmojiFont"" size="2" color="#17365D" face="Century Gothic,sans-serif"><span style="font-size:10pt"><b>UNIVERSITY
 OF CALIFORNIA, MERCED</b></span></font><font style="font-family:Century Gothic,sans-serif,serif,"EmojiFont"" size="2" color="navy" face="Century Gothic,sans-serif"><span style="font-size:10pt"><b><br>
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 S&E2. Rm. 382.</span></font></span></font><b><br>
</b></span></font><a href="mailto:pbrown3@ucmerced.edu" rel="noopener noreferrer" title="Cmd+Click or tap to follow the link" id="m_8063531740850197925LPNoLP" target="_blank"><font style="font-family:Century Gothic,sans-serif,serif,"EmojiFont"" size="2" color="blue" face="Century Gothic,sans-serif"><span style="font-size:9pt"></span></font></a></span></font></div>
<div style="margin:0"><font style="font-family:Calibri,sans-serif,serif,"EmojiFont"" size="2" face="Calibri,sans-serif"><span style="font-size:11pt"><font style="font-family:Century Gothic,sans-serif,serif,"EmojiFont"" size="2" color="#376092" face="Century Gothic,sans-serif"><span style="font-size:9pt"><span class="m_8063531740850197925contextualExtensionHighlight m_8063531740850197925ms-font-color-themePrimary m_8063531740850197925ms-border-color-themePrimary m_8063531740850197925ident_295_333">5200
 North Lake Road, Merced, CA 95343</span></span></font></span></font><font style="font-family:Calibri,sans-serif,serif,"EmojiFont"" size="2" face="Calibri,sans-serif"><span style="font-size:11pt"><font style="font-family:Century Gothic,sans-serif,serif,"EmojiFont"" size="2" color="#DFB917" face="Century Gothic,sans-serif"><span style="font-size:10pt"><b><u><span style="font-family:"Century Gothic",sans-serif"><span style="font-size:8pt"><br>
</span><font style="font-family:Calibri,sans-serif,serif,"EmojiFont"" size="2" face="Calibri,sans-serif"><span style="font-size:11pt"><font style="font-family:Century Gothic,sans-serif,serif,"EmojiFont"" size="2" color="#DFB917" face="Century Gothic,sans-serif"><span style="font-size:10pt"><b><u>______________________________<wbr>_________</u></b></span></font><font style="font-family:Century Gothic,sans-serif,serif,"EmojiFont"" size="2" color="#17365D" face="Century Gothic,sans-serif"><span style="font-size:10pt" lang="it"><b><br>
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</div><br><br clear="all"><div><br></div>-- <br><div class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div><div dir="ltr">Miriam Barlow</div><div dir="ltr">Founding Faculty and Associate Professor<div>Chair, Quantitative and Systems Biology</div><div>University of California, Merced</div><div><br></div><div>209.228.4174</div><div><a href="mailto:miriam.barlow@gmail.com" target="_blank">miriam.barlow@gmail.com</a></div><div><br></div></div></div></div></div>
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