[QSB-grads] MCB seminar Tuesday Feb 14 @ noon in SE1 270K, Xuecai (Susan) Ge

[Frederick Wolf]

MCB faculty and students,

Our next MCB seminar features new faculty member Xuecai (Susan) Ge. Feel free to invite anyone that may be interested in her research.


Integration of cell signaling in neural development and neurological diseases: a prospective overview
Xuecai (Susan) Ge
Tuesday, February 14, 2017 @ noon in SE1 270K

Abstract
Signal transduction is the choreography of the brain development. Mis-regulation of cell signaling underlies many developmental defects. My research will focus on the spatial and temporal integration of Hedgehog signaling with other signaling pathways in brain development and its related diseases.



My previous study revealed the integration of the Neuropilin-PDE4D-Hedgehog signaling in the cerebellar development and its related pediatric brain tumor. This study highlighted PDE4D as a new regulator of Hedgehog signaling and its related brain tumors. My future research will answer how PDE4D spatial localization specifically regulate Hedgehog pathway.  The other focus of my lab is how Hedgehog signaling temporally integrates with phosphatidylinositol signaling to control cell proliferation and differentiation in the developing cerebellum. RNA-seq analysis revealed a surge in the expression of a group of phosphatidylinositol related proteins right after neural precursors exist cell cycle in the developing cerebellum. It is intriguing to explore how these proteins control phosphatidylinositol lipid metabolism to interplay with Hedgehog signaling and to regulate brain development.



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Fred W Wolf, Ph.D.
Assistant Professor
School of Natural Sciences
UC Merced
5200 N. Lake Rd. Merced, CA 95343
415.370.1132
fwolf at ucmerced.edu<mailto:fwolf at ucmerced.edu>
http://faculty.ucmerced.edu/fwolf/
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