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MCB faculty and students,
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<div class="">Our next MCB seminar features new faculty member Xuecai (Susan) Ge. Feel free to invite anyone that may be interested in her research.</div>
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<b class="">Integration of cell signaling in neural development and neurological diseases: a prospective overview</b></div>
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<b class="">Xuecai (Susan) Ge</b></div>
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<b class="">Tuesday, February 14, 2017 @ noon in SE1 270K</b></div>
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Signal transduction is the choreography of the brain development. Mis-regulation of cell signaling underlies many developmental defects. My research will focus on the spatial and temporal integration of Hedgehog signaling with other signaling pathways in brain
development and its related diseases.</div>
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My previous study revealed the integration of the Neuropilin-PDE4D-Hedgehog signaling in the cerebellar development and its related pediatric brain tumor. This study highlighted PDE4D as a new regulator of Hedgehog signaling and its related brain tumors. My
future research will answer how PDE4D spatial localization specifically regulate Hedgehog pathway. The other focus of my lab is how Hedgehog signaling temporally integrates with phosphatidylinositol signaling to control cell proliferation and differentiation
in the developing cerebellum. RNA-seq analysis revealed a surge in the expression of a group of phosphatidylinositol related proteins right after neural precursors exist cell cycle in the developing cerebellum. It is intriguing to explore how these proteins
control phosphatidylinositol lipid metabolism to interplay with Hedgehog signaling and to regulate brain development.</div>
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Fred W Wolf, Ph.D.<br class="">
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Assistant Professor<br class="">
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School of Natural Sciences<br class="">
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UC Merced<br class="">
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5200 N. Lake Rd. Merced, CA 95343<br class="">
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415.370.1132<br class="">
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<a href="mailto:fwolf@ucmerced.edu" class="">fwolf@ucmerced.edu</a><br class="">
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