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<p style="background:white"><span class="xgmail-xcontentpasted0"><span style="font-size:12.0pt;color:black">Dear enthusiasts of the SLAAM seminars,</span></span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
<p style="background:white;caret-color: rgb(0, 0, 0);font-variant-caps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">
<span class="xgmail-xcontentpasted0"><span style="font-size:12.0pt;color:black">We are excited to announce that the next <a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__physics.ucmerced.edu_slaam&d=DwMF-g&c=WO-RGvefibhHBZq3fL85hQ&r=6T170XR90Za4-nl9r1e8-WfEJbvH5g5hJbA9UumqfWQ&m=blUGUqAYGAyOmfcA6wfbX1KdEHN6f7rlZXR4X15CvyI8uL__ETi299NvZD96qFU6&s=MXUKX4H_djd0Ct_0kzRBhKPqez6-ARSHV2ymcIgm0vs&e=" title="https://urldefense.proofpoint.com/v2/url?u=https-3A__physics.ucmerced.edu_slaam&d=DwMF-g&c=WO-RGvefibhHBZq3fL85hQ&r=6T170XR90Za4-nl9r1e8-WfEJbvH5g5hJbA9UumqfWQ&m=blUGUqAYGAyOmfcA6wfbX1KdEHN6f7rlZXR4X15CvyI8uL__ETi299NvZD96qFU6&s=MXUKX4H_djd0Ct_0kzRBhKPqez"><span style="color:#0563C1">Soft
Living Active and Adaptive Matter (SLAAM)</span></a> seminar will be given by <b>Dr. </b></span></span><b><span style="font-size:12.0pt;color:#242424">Isabella Graf</span></b><span class="apple-converted-space"><b><span style="font-size:12.0pt;color:black"> </span></b></span><span class="xgmail-xcontentpasted0"><span style="font-size:12.0pt;color:black">(</span></span><span style="font-size:12.0pt;color:#242424">Yale
University</span><span class="xgmail-xcontentpasted0"><span style="font-size:12.0pt;color:black">) on <b>Monday, November 13, </b>at <b>9am Pacific/11am Central/12 noon Eastern time (US)</b>, with the title:</span></span><b><span style="font-size:12.0pt;color:#242424"><o:p></o:p></span></b></p>
<p class="xgmail-xmsonormal"><b><span style="font-size:12.0pt;color:#242424">“</span></b><b><i><span style="font-size:12.0pt;color:black">A bifurcation integrates information from many noisy ion channels and allows for milli-Kelvin thermal sensitivity in the
snake pit organ</span></i></b><b><span style="font-size:12.0pt;color:black">”<o:p></o:p></span></b></p>
<p style="background:white"><span class="xgmail-xcontentpasted0"><span style="font-size:12.0pt;color:black">Please join at the link below to attend:</span></span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
<p style="background:white;caret-color: rgb(0, 0, 0);font-variant-caps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">
<span style="font-size:12.0pt;color:black"><a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__ucmerced.zoom.us_j_92693607475-3Fpwd-3DTnI5dDhRRnYvejNZK2xNN0s4M0R5UT09&d=DwMF-g&c=WO-RGvefibhHBZq3fL85hQ&r=6T170XR90Za4-nl9r1e8-WfEJbvH5g5hJbA9UumqfWQ&m=O8qMRgNKyoPvtsVZg8ZfBNtLCUDyJgxTRW3qBCkxor7FWyzclXdrZHLsUUJnajQo&s=Fc0LF7BKeY-N8RWCA1JZPtXHGcs7LT8bWaOKdgeG1FE&e=" title="https://urldefense.proofpoint.com/v2/url?u=https-3A__ucmerced.zoom.us_j_92693607475-3Fpwd-3DTnI5dDhRRnYvejNZK2xNN0s4M0R5UT09&d=DwMF-g&c=WO-RGvefibhHBZq3fL85hQ&r=6T170XR90Za4-nl9r1e8-WfEJbvH5g5hJbA9UumqfWQ&m=O8qMRgNKyoPvtsVZg8ZfBNtLCUDyJgxTRW3qBCkxor7FWyzc">https://ucmerced.zoom.us/j/92693607475?pwd=TnI5dDhRRnYvejNZK2xNN0s4M0R5UT09</a><o:p></o:p></span></p>
<p style="background:white;caret-color: rgb(0, 0, 0);font-variant-caps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">
<span class="xgmail-xcontentpasted0"><span style="font-size:12.0pt;color:black">Zoom Meeting ID: 926 9360 7475 | Passcode: 223642</span></span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
<p class="xgmail-xmsonormal" style="margin:0in;caret-color: rgb(0, 0, 0);font-variant-caps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">
<span style="font-size:12.0pt;color:black">As usual, there will be a 15 min informal Q&A at the end of the hour. Graduate students will have an opportunity to interact with the speaker in an informal setting during the "Meet the speaker" timeslot just after
the talk. Please join if the time works for you.<o:p></o:p></span></p>
<p style="background:white;caret-color: rgb(0, 0, 0);font-variant-caps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">
<span style="font-size:12.0pt;color:#242424">Please see more info in the flyer<span class="xgmail-xapple-converted-space"> </span><a href="https://physics.ucmerced.edu/sites/physics.ucmerced.edu/files/event/SLAAM/isabella_graf_slaam.pdf" title="https://physics.ucmerced.edu/sites/physics.ucmerced.edu/files/page/documents/mengqi_slaam.pdf">here</a><span class="xgmail-xapple-converted-space"> </span>and
in the text below: </span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
<p class="xgmail-xcontentpasted01" style="margin:0in;background:white"><span class="xgmail-xcontentpasted0"><b><span style="font-size:12.0pt;color:black">Abstract</span></b></span><span class="xgmail-xcontentpasted0"><span style="font-size:12.0pt;color:black">:</span></span><span class="apple-converted-space"><span style="font-size:12.0pt;color:black"> </span></span><span style="font-size:12.0pt;color:black">The
thermal imaging organ of pit vipers is a remarkable example for how biological systems integrate information from many noisy sensors into a collective response. Single nerve fibers innervating the organ robustly respond to milli-Kelvin changes in temperature,
even though the opening probability of each individual temperature-sensitive ion channel only changes by 0.1%. Here, we propose a mechanism for the integration of this noisy molecular information into an amplified response. Amplification arises due to proximity
to a dynamical bifurcation, separating a regime with frequent and regular firing of action potentials (APs), from one with irregular and infrequent firing. Near the transition, AP frequency can have an extremely sharp dependence on temperature, and most of
the information in molecular receptors is efficiently transmitted to AP firing even if additional noise corrupts the signal or readout. Our model explains several key features of experimental data. Most significantly, it predicts that the coefficient of variation
in the distribution of times between APs decreases for larger AP frequency. It also suggests that the intrinsic channel timescale may be slower than the timescale of the cell’s voltage dynamics, thereby leading to memory in the state of the channels.<o:p></o:p></span></p>
<p class="xgmail-xcontentpasted01" style="margin:0in;background:white"><span style="font-size:12.0pt;color:black"><o:p> </o:p></span></p>
<p class="xgmail-xcontentpasted01" style="margin:0in;background:white"><b><span style="font-size:12.0pt;color:black">Speaker bio:
</span></b><span class="xgmail-xcontentpasted0"><span style="font-size:12.0pt;color:black">Isabella Graf is a Postdoctoral Fellow in the Physics department at Yale University. She is broadly interested in using methods and tools of statistical mechanics, nonlinear
dynamics, and information theory to describe and help understand biological phenomena. Her current research in Ben Machta’s group focuses on signal amplification and information integration in biological sensory systems and on the phase behavior of mixtures
with many components. Before joining Yale University, she was a PhD student in Physics in Erwin Frey’s group at LMU Munich, Germany, where she worked on collective dynamics and self-organization in the context of the cell cytoskeleton and on non-equilibrium
self-assembly of heterogeneous structures. </span></span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
<p style="background:white"><span class="xgmail-xcontentpasted0"><span style="font-size:12.0pt;color:black">See you there! </span></span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
<p style="background:white;caret-color: rgb(0, 0, 0);font-variant-caps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">
<span class="xgmail-xcontentpasted0"><span style="font-size:12.0pt;color:black">Best regards,</span></span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
<p style="background:white;caret-color: rgb(0, 0, 0);font-variant-caps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">
<span class="xgmail-xcontentpasted0"><span style="font-size:12.0pt;color:black">Dan Beller</span></span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
<p style="margin-bottom:12.0pt;background:white;caret-color: rgb(0, 0, 0);font-variant-caps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">
<span class="xgmail-xcontentpasted0"><span style="font-size:12.0pt;color:black">on behalf of the SLAAM organizing team</span></span><span style="font-size:12.0pt;color:black"><br>
</span><span class="xgmail-xcontentpasted0"><span style="font-size:12.0pt;color:black">(Alexandra Tayar, Suraj Shankar, Daniel Beller, Kinjal Dasbiswas)</span></span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
<p style="background:white;caret-color: rgb(0, 0, 0);font-variant-caps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">
<span class="xgmail-xcontentpasted0"><i><span style="font-size:12.0pt;color:black">To join the SLAAM mailing list, please sign up <a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__docs.google.com_forms_d_e_1FAIpQLScTyzEuuE7TfrrapgP4tzN-5FoPSqbBhURUxa9-2Dzc8USnY1IPzA_viewform&d=DwMFAw&c=WO-RGvefibhHBZq3fL85hQ&r=6T170XR90Za4-nl9r1e8-WfEJbvH5g5hJbA9UumqfWQ&m=NK4EGo1VvrDiYSxdvOUJXgCkEAzTrQzNpQi-P59LZiKL_lMA3briJm9KQh9Y3suN&s=3hc1lEhiJwBLtMEr12Z9K5XtZaVlEfOZKYXGtXCjRDg&e=" title="https://urldefense.proofpoint.com/v2/url?u=https-3A__docs.google.com_forms_d_e_1FAIpQLScTyzEuuE7TfrrapgP4tzN-5FoPSqbBhURUxa9-2Dzc8USnY1IPzA_viewform&d=DwMFAw&c=WO-RGvefibhHBZq3fL85hQ&r=6T170XR90Za4-nl9r1e8-WfEJbvH5g5hJbA9UumqfWQ&m=NK4EGo1VvrDiYSxdvOUJXgCk">here</a>. If
you’re a postdoc interested in giving a SLAAM talk, we invite you to register your interest on that webform.</span></i></span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt"><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">Daniel Beller<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">Assistant Professor<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">Department of Physics and Astronomy<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">Johns Hopkins University<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">pages.jh.edu/dbeller3<o:p></o:p></span></p>
</div>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">(he/him/his)</span><span style="font-size:12.0pt"><o:p></o:p></span></p>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt"><o:p> </o:p></span></p>
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