<div style="font-family: Times New Roman, serif; font-size: 18px;">I'm not Bob. You might want to resend this.</div><div style="font-family: Times New Roman, serif; font-size: 18px;"><p style="margin:0px;font:18px "Times New Roman"">Thanks,</p><p style="margin:0px;font:18px "Times New Roman"">Richard (Dick) Gordon</p><p style="margin:0px;font:18px "Times New Roman"">Theoretical Biologist</p><p style="margin:0px;font:18px "Times New Roman"">DickGordonCan@protonmail.com</p><p style="margin:0px;font:18px "Times New Roman"">Retired from University of Manitoba</p><p style="margin:0px;font:18px "Times New Roman"">Volunteer at Gulf Specimen Marine Lab & Aquarium (http://www.gulfspecimen.org/gulf-specimen-lab-staff/, https://www.facebook.com/GulfSpecimenAquarium/)</p><p style="margin:0px;font:18px "Times New Roman"">DickGordonCan@protonmail.com (ask if you want access to my papers)</p><p style="margin:0px;font:18px "Times New Roman"">home: 1-(204) 767-2164</p><p style="margin: 0px; font: 18px "Times New Roman"; color: rgb(0, 0, 255);"><span style="text-decoration:underline"><a href="http://orcid.org/0000-0003-4970-9953">http://orcid.org/0000-0003-4970-9953</a></span></p><p style="margin: 0px; font: 18px "Times New Roman"; color: rgb(0, 0, 255);"><span style="text-decoration:underline"><a href="http://tinyurl.com/RichardGordonBooks">http://tinyurl.com/RichardGordonBooks</a></span></p><p style="margin: 0px; font: 18px "Times New Roman"; color: rgb(0, 0, 255);"><span style="text-decoration:underline">now on Central Standard Time</span></p><br></div><div style="font-family: Times New Roman, serif; font-size: 18px;"><br></div>
<div class="protonmail_signature_block" style="font-family: Times New Roman, serif; font-size: 18px;">
<div class="protonmail_signature_block-user protonmail_signature_block-empty">
</div>
<div class="protonmail_signature_block-proton">
Sent with <a target="_blank" href="https://proton.me/" rel="noopener noreferrer">Proton Mail</a> secure email.
</div>
</div>
<div style="font-family: Times New Roman, serif; font-size: 18px;"><br></div><div class="protonmail_quote">
------- Original Message -------<br>
On Monday, November 6th, 2023 at 4:20 PM, SLAAM Distribution List <slaam@lists.ucmerced.edu> wrote:<br><br>
<blockquote class="protonmail_quote" type="cite">
<span class="" style="font-size: 14px;">Hey Bob,</span>
<div class=""><span class="" style="font-size: 14px;"><br class="">
</span></div>
<div class=""><span class="" style="font-size: 14px;">The speaker for next week’s SLAAM Seminar seems to be an expert in dealing with noisy signals. I guess she might have some idea about your tricky noisy traces? (not 100% sure though) There is an hour-long
timeslot just after the talk to meet with her and talk whatever you want. </span></div>
<div class=""><span class="" style="font-size: 14px;"><br class="">
</span></div>
<div class=""><span class="" style="font-size: 14px;">Just FYI, in case you are interested! </span></div>
<div class=""><span class="" style="font-size: 14px;"><br class="">
</span></div>
<div class=""><span class="" style="font-size: 14px;">Best,</span></div>
<div class=""><span class="" style="font-size: 14px;">Mengqi</span></div>
<div class=""><br class="">
<div>
<blockquote class="" type="cite">
<div class="">On Nov 6, 2023, at 4:35 PM, SLAAM Distribution List <<a class="" href="mailto:slaam@lists.ucmerced.edu" rel="noreferrer nofollow noopener" target="_blank">slaam@lists.ucmerced.edu</a>> wrote:</div>
<br class="Apple-interchange-newline">
<div class="">
<div style="page: WordSection1; caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;" class="WordSection1">
<p class="" style="background-color: white;"><span class="xgmail-xcontentpasted0"><span class="" style="font-size: 12pt;">Dear enthusiasts of the SLAAM seminars,</span></span><span class="" style="font-size: 12pt;"></span></p>
<p class="" style="background-color: white; caret-color: rgb(0, 0, 0); font-variant-caps: normal; text-align: start; -webkit-text-stroke-width: 0px; word-spacing: 0px;">
<span class="xgmail-xcontentpasted0"><span class="" style="font-size: 12pt;">We are excited to announce that the next <a class="" style="color: rgb(5, 99, 193); text-decoration: underline;" title="https://urldefense.proofpoint.com/v2/url?u=https-3A__physics.ucmerced.edu_slaam&d=DwMF-g&c=WO-RGvefibhHBZq3fL85hQ&r=6T170XR90Za4-nl9r1e8-WfEJbvH5g5hJbA9UumqfWQ&m=blUGUqAYGAyOmfcA6wfbX1KdEHN6f7rlZXR4X15CvyI8uL__ETi299NvZD96qFU6&s=MXUKX4H_djd0Ct_0kzRBhKPqez" href="https://urldefense.proofpoint.com/v2/url?u=https-3A__physics.ucmerced.edu_slaam&d=DwMF-g&c=WO-RGvefibhHBZq3fL85hQ&r=6T170XR90Za4-nl9r1e8-WfEJbvH5g5hJbA9UumqfWQ&m=blUGUqAYGAyOmfcA6wfbX1KdEHN6f7rlZXR4X15CvyI8uL__ETi299NvZD96qFU6&s=MXUKX4H_djd0Ct_0kzRBhKPqez6-ARSHV2ymcIgm0vs&e=" rel="noreferrer nofollow noopener" target="_blank"><span class="" style="color: rgb(5, 99, 193);">Soft
Living Active and Adaptive Matter (SLAAM)</span></a> seminar will be given by <b class="">Dr. </b></span></span><b class=""><span class="" style="font-size: 12pt; color: rgb(36, 36, 36);">Isabella Graf</span></b><span class="apple-converted-space"><b class=""><span class="" style="font-size: 12pt;"> </span></b></span><span class="xgmail-xcontentpasted0"><span class="" style="font-size: 12pt;">(</span></span><span class="" style="font-size: 12pt; color: rgb(36, 36, 36);">Yale
University</span><span class="xgmail-xcontentpasted0"><span class="" style="font-size: 12pt;">) on <b class="">Monday, November 13, </b>at <b class="">9am Pacific/11am Central/12 noon Eastern time (US)</b>, with the title:</span></span><b class=""><span class="" style="font-size: 12pt; color: rgb(36, 36, 36);"></span></b></p>
<p style="margin-right: 0in; margin-left: 0in; font-size: 11pt; font-family: Calibri, sans-serif;" class="xgmail-xmsonormal">
<b class=""><span class="" style="font-size: 12pt; color: rgb(36, 36, 36);">“</span></b><b class=""><i class=""><span class="" style="font-size: 12pt;">A bifurcation integrates information from many noisy ion channels and allows for milli-Kelvin thermal sensitivity
in the snake pit organ</span></i></b><b class=""><span class="" style="font-size: 12pt;">”</span></b></p>
<p class="" style="background-color: white;"><span class="xgmail-xcontentpasted0"><span class="" style="font-size: 12pt;">Please join at the link below to attend:</span></span><span class="" style="font-size: 12pt;"></span></p>
<p class="" style="background-color: white; caret-color: rgb(0, 0, 0); font-variant-caps: normal; text-align: start; -webkit-text-stroke-width: 0px; word-spacing: 0px;">
<span class="" style="font-size: 12pt;"><a class="" style="color: rgb(5, 99, 193); text-decoration: underline;" title="https://urldefense.proofpoint.com/v2/url?u=https-3A__ucmerced.zoom.us_j_92693607475-3Fpwd-3DTnI5dDhRRnYvejNZK2xNN0s4M0R5UT09&d=DwMF-g&c=WO-RGvefibhHBZq3fL85hQ&r=6T170XR90Za4-nl9r1e8-WfEJbvH5g5hJbA9UumqfWQ&m=O8qMRgNKyoPvtsVZg8ZfBNtLCUDyJgxTRW3qBCkxor7FWyzc" href="https://urldefense.proofpoint.com/v2/url?u=https-3A__ucmerced.zoom.us_j_92693607475-3Fpwd-3DTnI5dDhRRnYvejNZK2xNN0s4M0R5UT09&d=DwMF-g&c=WO-RGvefibhHBZq3fL85hQ&r=6T170XR90Za4-nl9r1e8-WfEJbvH5g5hJbA9UumqfWQ&m=O8qMRgNKyoPvtsVZg8ZfBNtLCUDyJgxTRW3qBCkxor7FWyzclXdrZHLsUUJnajQo&s=Fc0LF7BKeY-N8RWCA1JZPtXHGcs7LT8bWaOKdgeG1FE&e=" rel="noreferrer nofollow noopener" target="_blank">https://ucmerced.zoom.us/j/92693607475?pwd=TnI5dDhRRnYvejNZK2xNN0s4M0R5UT09</a></span></p>
<p class="" style="background-color: white; caret-color: rgb(0, 0, 0); font-variant-caps: normal; text-align: start; -webkit-text-stroke-width: 0px; word-spacing: 0px;">
<span class="xgmail-xcontentpasted0"><span class="" style="font-size: 12pt;">Zoom Meeting ID: 926 9360 7475 | Passcode: 223642</span></span><span class="" style="font-size: 12pt;"></span></p>
<div class="" style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0); font-variant-caps: normal; text-align: start; -webkit-text-stroke-width: 0px; word-spacing: 0px;">
<span class="" style="font-size: 12pt;">As usual, there will be a 15 min informal Q&A at the end of the hour. Graduate students will have an opportunity to interact with the speaker in an informal setting during the "Meet the speaker" timeslot just after the
talk. Please join if the time works for you.</span></div>
<p class="" style="background-color: white; caret-color: rgb(0, 0, 0); font-variant-caps: normal; text-align: start; -webkit-text-stroke-width: 0px; word-spacing: 0px;">
<span class="" style="font-size: 12pt; color: rgb(36, 36, 36);">Please see more info in the flyer<span class="xgmail-xapple-converted-space"> </span><a class="" style="color: rgb(5, 99, 193); text-decoration: underline;" title="https://physics.ucmerced.edu/sites/physics.ucmerced.edu/files/page/documents/mengqi_slaam.pdf" href="https://physics.ucmerced.edu/sites/physics.ucmerced.edu/files/event/SLAAM/isabella_graf_slaam.pdf" rel="noreferrer nofollow noopener" target="_blank">here</a><span class="xgmail-xapple-converted-space"> </span>and
in the text below: </span><span class="" style="font-size: 12pt;"></span></p>
<div class="" style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif; background-color: white;">
<span class="xgmail-xcontentpasted0"><b class=""><span class="" style="font-size: 12pt;">Abstract</span></b></span><span class="xgmail-xcontentpasted0"><span class="" style="font-size: 12pt;">:</span></span><span class="apple-converted-space"><span class="" style="font-size: 12pt;"> </span></span><span class="" style="font-size: 12pt;">The
thermal imaging organ of pit vipers is a remarkable example for how biological systems integrate information from many noisy sensors into a collective response. Single nerve fibers innervating the organ robustly respond to milli-Kelvin changes in temperature,
even though the opening probability of each individual temperature-sensitive ion channel only changes by 0.1%. Here, we propose a mechanism for the integration of this noisy molecular information into an amplified response. Amplification arises due to proximity
to a dynamical bifurcation, separating a regime with frequent and regular firing of action potentials (APs), from one with irregular and infrequent firing. Near the transition, AP frequency can have an extremely sharp dependence on temperature, and most of
the information in molecular receptors is efficiently transmitted to AP firing even if additional noise corrupts the signal or readout. Our model explains several key features of experimental data. Most significantly, it predicts that the coefficient of variation
in the distribution of times between APs decreases for larger AP frequency. It also suggests that the intrinsic channel timescale may be slower than the timescale of the cell’s voltage dynamics, thereby leading to memory in the state of the channels.</span></div>
<div class="" style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif; background-color: white;">
<span class="" style="font-size: 12pt;"> </span></div>
<div class="" style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif; background-color: white;">
<b class=""><span class="" style="font-size: 12pt;">Speaker bio:<span class="Apple-converted-space"> </span></span></b><span class="xgmail-xcontentpasted0"><span class="" style="font-size: 12pt;">Isabella Graf is a Postdoctoral Fellow in the Physics department
at Yale University. She is broadly interested in using methods and tools of statistical mechanics, nonlinear dynamics, and information theory to describe and help understand biological phenomena. Her current research in Ben Machta’s group focuses on signal
amplification and information integration in biological sensory systems and on the phase behavior of mixtures with many components. Before joining Yale University, she was a PhD student in Physics in Erwin Frey’s group at LMU Munich, Germany, where she worked
on collective dynamics and self-organization in the context of the cell cytoskeleton and on non-equilibrium self-assembly of heterogeneous structures. </span></span><span class="" style="font-size: 12pt;"></span></div>
<p class="" style="background-color: white;"><span class="xgmail-xcontentpasted0"><span class="" style="font-size: 12pt;">See you there! </span></span><span class="" style="font-size: 12pt;"></span></p>
<p class="" style="background-color: white; caret-color: rgb(0, 0, 0); font-variant-caps: normal; text-align: start; -webkit-text-stroke-width: 0px; word-spacing: 0px;">
<span class="xgmail-xcontentpasted0"><span class="" style="font-size: 12pt;">Best regards,</span></span><span class="" style="font-size: 12pt;"></span></p>
<p class="" style="background-color: white; caret-color: rgb(0, 0, 0); font-variant-caps: normal; text-align: start; -webkit-text-stroke-width: 0px; word-spacing: 0px;">
<span class="xgmail-xcontentpasted0"><span class="" style="font-size: 12pt;">Dan Beller</span></span><span class="" style="font-size: 12pt;"></span></p>
<p class="" style="margin-bottom: 12pt; background-color: white; caret-color: rgb(0, 0, 0); font-variant-caps: normal; text-align: start; -webkit-text-stroke-width: 0px; word-spacing: 0px;">
<span class="xgmail-xcontentpasted0"><span class="" style="font-size: 12pt;">on behalf of the SLAAM organizing team</span></span><span class="" style="font-size: 12pt;"><br class="">
</span><span class="xgmail-xcontentpasted0"><span class="" style="font-size: 12pt;">(Alexandra Tayar, Suraj Shankar, Daniel Beller, Kinjal Dasbiswas)</span></span><span class="" style="font-size: 12pt;"></span></p>
<p class="" style="background-color: white; caret-color: rgb(0, 0, 0); font-variant-caps: normal; text-align: start; -webkit-text-stroke-width: 0px; word-spacing: 0px;">
<span class="xgmail-xcontentpasted0"><i class=""><span class="" style="font-size: 12pt;">To join the SLAAM mailing list, please sign up <a class="" style="color: rgb(5, 99, 193); text-decoration: underline;" title="https://urldefense.proofpoint.com/v2/url?u=https-3A__docs.google.com_forms_d_e_1FAIpQLScTyzEuuE7TfrrapgP4tzN-5FoPSqbBhURUxa9-2Dzc8USnY1IPzA_viewform&d=DwMFAw&c=WO-RGvefibhHBZq3fL85hQ&r=6T170XR90Za4-nl9r1e8-WfEJbvH5g5hJbA9UumqfWQ&m=NK4EGo1VvrDiYSxdvOUJXgCk" href="https://urldefense.proofpoint.com/v2/url?u=https-3A__docs.google.com_forms_d_e_1FAIpQLScTyzEuuE7TfrrapgP4tzN-5FoPSqbBhURUxa9-2Dzc8USnY1IPzA_viewform&d=DwMFAw&c=WO-RGvefibhHBZq3fL85hQ&r=6T170XR90Za4-nl9r1e8-WfEJbvH5g5hJbA9UumqfWQ&m=NK4EGo1VvrDiYSxdvOUJXgCkEAzTrQzNpQi-P59LZiKL_lMA3briJm9KQh9Y3suN&s=3hc1lEhiJwBLtMEr12Z9K5XtZaVlEfOZKYXGtXCjRDg&e=" rel="noreferrer nofollow noopener" target="_blank">here</a>. If
you’re a postdoc interested in giving a SLAAM talk, we invite you to register your interest on that webform.</span></i></span><span class="" style="font-size: 12pt;"></span></p>
<div class="" style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;">
<span class="" style="font-size: 12pt;"> </span></div>
<div class="">
<div class="" style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;">
<span class="" style="font-size: 9pt; font-family: Helvetica;">Daniel Beller</span></div>
<div class="" style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;">
<span class="" style="font-size: 9pt; font-family: Helvetica;">Assistant Professor</span></div>
<div class="" style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;">
<span class="" style="font-size: 9pt; font-family: Helvetica;">Department of Physics and Astronomy</span></div>
<div class="" style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;">
<span class="" style="font-size: 9pt; font-family: Helvetica;">Johns Hopkins University</span></div>
<div class="" style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;">
<span class="" style="font-size: 9pt; font-family: Helvetica;"><a class="" style="color: rgb(5, 99, 193); text-decoration: underline;" href="http://pages.jh.edu/dbeller3" rel="noreferrer nofollow noopener" target="_blank">pages.jh.edu/dbeller3</a></span></div>
</div>
<div class="" style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;">
<span class="" style="font-size: 9pt; font-family: Helvetica;">(he/him/his)</span><span class="" style="font-size: 12pt;"></span></div>
<div class="">
<div class="" style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;">
<span class="" style="font-size: 12pt;"> </span></div>
</div>
</div>
<span class="" style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; float: none; display: inline !important;">_______________________________________________</span><br class="" style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;">
<span class="" style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; float: none; display: inline !important;">Slaam
mailing list</span><br class="" style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;">
<a class="" style="color: rgb(5, 99, 193); text-decoration: underline; font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;" href="mailto:Slaam@lists.ucmerced.edu" rel="noreferrer nofollow noopener" target="_blank">Slaam@lists.ucmerced.edu</a><br class="" style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;">
<a class="" style="color: rgb(5, 99, 193); text-decoration: underline; font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;" href="https://lists.ucmerced.edu/mailman/listinfo/slaam" rel="noreferrer nofollow noopener" target="_blank">https://lists.ucmerced.edu/mailman/listinfo/slaam</a></div>
</blockquote>
</div>
<br class="">
</div>
</blockquote><br>
</div>