<html>
<head>
<meta http-equiv="Content-Type" content="text/html; charset=Windows-1252">
<style type="text/css" style="display:none;"> P {margin-top:0;margin-bottom:0;} </style>
</head>
<body dir="ltr">
<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
<p style="font-family: "Segoe UI", "Segoe UI Web (West European)", "Segoe UI", -apple-system, BlinkMacSystemFont, Roboto, "Helvetica Neue", sans-serif; font-size: 15px; margin: 0in; background: white; color: rgb(36, 36, 36);">
<span class="x_contentpasted0" style="margin:0px"><span style="font-size: 12pt; margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black;" class="ContentPasted0">Dear enthusiasts of the SLAAM seminars,</span></span><span style="font-size:12pt;margin:0px"></span></p>
<p style="font-family: "Segoe UI", "Segoe UI Web (West European)", "Segoe UI", -apple-system, BlinkMacSystemFont, Roboto, "Helvetica Neue", sans-serif; font-size: 15px; margin: 0in; background: white; color: rgb(36, 36, 36);">
<span class="x_contentpasted0" style="margin:0px"><span style="font-size: 12pt; margin: 0px; color: black;" class="ContentPasted0"> </span></span><span style="font-size:12pt;margin:0px"></span></p>
<p class="x_MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif; background: white; color: rgb(36, 36, 36);">
<span class="x_contentpasted0" style="margin:0px"><span style="font-size: 12pt; margin: 0px; color: black;" class="ContentPasted0">We are excited to announce that the next <a href="https://physics.ucmerced.edu/slaam" target="_blank" rel="noopener noreferrer" data-auth="NotApplicable" title="https://physics.ucmerced.edu/slaam" data-linkindex="0" style="margin: 0px; text-decoration: underline; color: rgb(5, 99, 193);" class="ContentPasted0" data-loopstyle="linkonly"><span style="margin:0px">Soft
Living Active and Adaptive Matter (SLAAM)</span></a> seminar will be given by <b class="ContentPasted0">Dr. Patrick McCall
<span class="ContentPasted0"> </span></b>(TU Dresden and Max Planck Institute) on <b class="ContentPasted0">Monday, June 12th, </b>at <b class="ContentPasted0">9am Pacific (</b><span class="ContentPasted0">11am Central US/12 noon Eastern time (US)/1800 Central
European/9:30 pm India/12 am China)</span><b class="ContentPasted0"> </b>with the title:</span></span><span style="font-size:12pt;margin:0px"></span></p>
<p class="x_MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif; background: white; color: rgb(36, 36, 36);">
<span style="font-size:12pt;margin:0px" class="ContentPasted0"> </span></p>
<p class="x_MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif; background: white; color: rgb(36, 36, 36);">
<b><span style="font-size:12pt;margin:0px" class="ContentPasted0">“Contrasting phases: insights into the physical properties of biomolecular condensates”</span></b></p>
<p style="font-family: "Segoe UI", "Segoe UI Web (West European)", "Segoe UI", -apple-system, BlinkMacSystemFont, Roboto, "Helvetica Neue", sans-serif; font-size: 15px; margin: 0in; background: white; color: rgb(36, 36, 36);">
<span class="x_contentpasted0" style="margin:0px"><span style="font-size: 12pt; margin: 0px; color: black;" class="ContentPasted0"> </span></span><span style="font-size:12pt;margin:0px"></span></p>
<p style="font-family: "Segoe UI", "Segoe UI Web (West European)", "Segoe UI", -apple-system, BlinkMacSystemFont, Roboto, "Helvetica Neue", sans-serif; font-size: 15px; margin: 0in; background: white; color: rgb(36, 36, 36);">
<span class="x_contentpasted0" style="margin:0px"><span style="font-size: 12pt; margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black;" class="ContentPasted0">Please join at the link below to attend:</span></span><span style="font-size:12pt;margin:0px"></span></p>
<p style="font-family: "Segoe UI", "Segoe UI Web (West European)", "Segoe UI", -apple-system, BlinkMacSystemFont, Roboto, "Helvetica Neue", sans-serif; font-size: 15px; margin: 0in; background: white; color: rgb(36, 36, 36);">
<span style="font-size: 12pt; margin: 0px; color: black;"><a href="https://ucmerced.zoom.us/j/92693607475?pwd=TnI5dDhRRnYvejNZK2xNN0s4M0R5UT09" target="_blank" rel="noopener noreferrer" data-auth="NotApplicable" title="https://ucmerced.zoom.us/j/92693607475?pwd=TnI5dDhRRnYvejNZK2xNN0s4M0R5UT09" data-linkindex="1" style="margin: 0px; text-decoration: underline; color: rgb(5, 99, 193);" class="ContentPasted0"><span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif;">https://ucmerced.zoom.us/j/92693607475?pwd=TnI5dDhRRnYvejNZK2xNN0s4M0R5UT09</span></a></span><span style="font-size:12pt;margin:0px"></span></p>
<p style="font-family: "Segoe UI", "Segoe UI Web (West European)", "Segoe UI", -apple-system, BlinkMacSystemFont, Roboto, "Helvetica Neue", sans-serif; font-size: 15px; margin: 0in; background: white; color: rgb(36, 36, 36);">
<span class="x_contentpasted0" style="margin:0px"><span style="font-size: 12pt; margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black;" class="ContentPasted0">Zoom Meeting ID: 926 9360 7475 | Passcode: 223642</span></span><span style="font-size:12pt;margin:0px"></span></p>
<p style="font-family: "Segoe UI", "Segoe UI Web (West European)", "Segoe UI", -apple-system, BlinkMacSystemFont, Roboto, "Helvetica Neue", sans-serif; font-size: 15px; margin: 0in; background: white; color: rgb(36, 36, 36);">
<span style="font-size: 12pt; margin: 0px; font-family: Calibri, Helvetica, sans-serif;" class="ContentPasted0"> </span></p>
<p style="font-family: "Segoe UI", "Segoe UI Web (West European)", "Segoe UI", -apple-system, BlinkMacSystemFont, Roboto, "Helvetica Neue", sans-serif; font-size: 15px; margin: 0in; background: white; color: rgb(36, 36, 36);">
<span style="font-size: 12pt; margin: 0px; font-family: Calibri, Helvetica, sans-serif;" class="ContentPasted0">Please see more info in the flyer </span><span style="font-size:12pt;margin:0px" class="ContentPasted0"><a href="https://physics.ucmerced.edu/sites/physics.ucmerced.edu/files/page/documents/patrick_mccall_slaam.pdf" title="https://physics.ucmerced.edu/sites/physics.ucmerced.edu/files/page/documents/patrick_mccall_slaam.pdf" data-loopstyle="linkonly" id="LPlnk417537">here</a><span class="x_apple-converted-space ContentPasted0" style="margin: 0px; font-family: Calibri, Helvetica, sans-serif;"> </span></span><span style="font-size: 12pt; margin: 0px; font-family: Calibri, Helvetica, sans-serif;" class="ContentPasted0">and
in the text below</span><span style="font-size:12pt;margin:0px" class="ContentPasted0">:</span></p>
<p style="font-family: "Segoe UI", "Segoe UI Web (West European)", "Segoe UI", -apple-system, BlinkMacSystemFont, Roboto, "Helvetica Neue", sans-serif; font-size: 15px; margin: 0in; background: white; color: rgb(36, 36, 36);">
<span style="font-size:12pt;margin:0px" class="ContentPasted0"><br>
</span></p>
<p style="font-family: "Segoe UI", "Segoe UI Web (West European)", "Segoe UI", -apple-system, BlinkMacSystemFont, Roboto, "Helvetica Neue", sans-serif; font-size: 15px; margin: 0in; background: white; color: rgb(36, 36, 36);">
<span style="font-size: 12pt; margin: 0px; font-family: Calibri, Helvetica, sans-serif;" class="ContentPasted0 ContentPasted1"><b>Abstract</b></span></p>
<p style="font-family: "Segoe UI", "Segoe UI Web (West European)", "Segoe UI", -apple-system, BlinkMacSystemFont, Roboto, "Helvetica Neue", sans-serif; font-size: 15px; margin: 0in; background: white; color: rgb(36, 36, 36);">
<span style="font-size: 12pt; margin: 0px; font-family: Calibri, Helvetica, sans-serif;" class="ContentPasted0 ContentPasted1">Many compartments within living cells exist as condensed fluid phases demixed from the surrounding solution. These biomolecular condensates
are enriched in many distinct proteins and nucleic acids and are thought to provide unique microenvironments for cellular biochemistry. Although the molecular composition of these multi-component condensates is crucial to their identity and physical properties,
challenges in composition measurement have largely precluded establishment of a quantitative physical picture for these phases. In this talk, I’ll describe our development of a label-free method based on quantitative (optical) phase microscopy to efficiently
and precisely measure the composition and shape of micron-sized reconstituted biomolecular condensates. In addition to dynamic and temperature-dependent measurements in binary systems, I will present a general procedure to measure composition in multi-component
condensates, which we validate by measuring the tie-lines and binodals for a ternary mixture containing RNA and the full-length RNA-binding protein FUS. Finally, I will discuss implications of our composition measurements for other physical properties of condensates
(e.g. mechanical, dielectric, surface), and speculate on potential biological consequences of property modulation.</span></p>
<p style="font-family: "Segoe UI", "Segoe UI Web (West European)", "Segoe UI", -apple-system, BlinkMacSystemFont, Roboto, "Helvetica Neue", sans-serif; font-size: 15px; margin: 0in; background: white; color: rgb(36, 36, 36);">
<span style="font-size:12pt;margin:0px" class="ContentPasted0 ContentPasted1"></p>
<div><br class="ContentPasted1">
</div>
<div><br class="ContentPasted1">
</div>
<div class="ContentPasted1"><span style="font-family: Calibri, Helvetica, sans-serif;"><b>About the speaker:</b></span></div>
<div><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt;">Patrick is a postdoctoral researcher working jointly with Jan Brugués in the Excellence Cluster: Physics of Life at TU Dresden and Tony Hyman at the Max Planck Institute of Molecular
Cell Biology and Genetics. By combining biochemical reconstitution with light microscopy and tools from soft matter physics, his research seeks to illuminate the molecular basis and physical properties of self-organized sub-cellular structures, such as biomolecular
condensates. He earned his PhD in Physics from the University of Chicago in 2017 advised by Margaret Gardel, where he studied the influence of non-equilibrium activity on the mechanics and dynamics of actin-based structures.</span><br>
</div>
<div><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt;"><br>
</span></div>
<div><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt;">Hope to see you there!</span></div>
<div><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt;" class="ContentPasted2">Best regards,
<div>Kinjal Dasbiswas</div>
<div><br class="ContentPasted2">
</div>
<div class="ContentPasted2">on behalf of the SLAAM organizing team</div>
<div class="ContentPasted2">(Alexandra Tayar, Suraj Shankar, Daniel Beller, Kinjal Dasbiswas)</div>
<div><br class="ContentPasted2">
</div>
To join the SLAAM mailing list, please sign up <a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__docs.google.com_forms_d_e_1FAIpQLScTyzEuuE7TfrrapgP4tzN-5FoPSqbBhURUxa9-2Dzc8USnY1IPzA_viewform&d=DwMFAw&c=WO-RGvefibhHBZq3fL85hQ&r=6T170XR90Za4-nl9r1e8-WfEJbvH5g5hJbA9UumqfWQ&m=NK4EGo1VvrDiYSxdvOUJXgCkEAzTrQzNpQi-P59LZiKL_lMA3briJm9KQh9Y3suN&s=3hc1lEhiJwBLtMEr12Z9K5XtZaVlEfOZKYXGtXCjRDg&e=" title="https://urldefense.proofpoint.com/v2/url?u=https-3A__docs.google.com_forms_d_e_1FAIpQLScTyzEuuE7TfrrapgP4tzN-5FoPSqbBhURUxa9-2Dzc8USnY1IPzA_viewform&d=DwMFAw&c=WO-RGvefibhHBZq3fL85hQ&r=6T170XR90Za4-nl9r1e8-WfEJbvH5g5hJbA9UumqfWQ&m=NK4EGo1VvrDiYSxdvOUJXgCkEAzTrQzNpQi-P59LZiKL_lMA3briJm9KQh9Y3suN&s=3hc1lEhiJwBLtMEr12Z9K5XtZaVlEfOZKYXGtXCjRDg&e=" data-loopstyle="linkonly" id="LPNoLPOWALinkPreview">
here</a>. If you’re a postdoc interested in giving a SLAAM talk, we invite you to register your interest on that webform.<br>
<div class="_Entity _EType_OWALinkPreview _EId_OWALinkPreview _EReadonly_1"></div>
<div style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(36, 36, 36); background-color: white;">
<br>
</div>
</span></div>
</span>
<p></p>
<p style="font-family: "Segoe UI", "Segoe UI Web (West European)", "Segoe UI", -apple-system, BlinkMacSystemFont, Roboto, "Helvetica Neue", sans-serif; font-size: 15px; margin: 0in; background: white; color: rgb(36, 36, 36);">
<span style="font-size:12pt;margin:0px" class="ContentPasted0"><br>
</span></p>
<p style="font-family: "Segoe UI", "Segoe UI Web (West European)", "Segoe UI", -apple-system, BlinkMacSystemFont, Roboto, "Helvetica Neue", sans-serif; font-size: 15px; margin: 0in; background: white; color: rgb(36, 36, 36);">
<span style="font-size:12pt;margin:0px" class="ContentPasted0"><br>
</span></p>
<p style="font-family: "Segoe UI", "Segoe UI Web (West European)", "Segoe UI", -apple-system, BlinkMacSystemFont, Roboto, "Helvetica Neue", sans-serif; font-size: 15px; margin: 0in; background: white; color: rgb(36, 36, 36);">
<span style="font-size:12pt;margin:0px" class="ContentPasted0"><br>
</span></p>
<p style="font-family: "Segoe UI", "Segoe UI Web (West European)", "Segoe UI", -apple-system, BlinkMacSystemFont, Roboto, "Helvetica Neue", sans-serif; font-size: 15px; margin: 0in; background: white; color: rgb(36, 36, 36);">
<span style="font-size:12pt;margin:0px" class="ContentPasted0"><br>
</span></p>
<br>
</div>
</body>
</html>