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<p class="MsoNormal"><span style="font-size:12.0pt;color:black">Dear enthusiasts of the SLAAM seminars,<o:p></o:p></span></p>
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<span style="font-size:12.0pt;color:black"> <o:p></o:p></span></p>
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<span style="font-size:12.0pt;color:black">We hope your 2023 is off to a great start! We invite you to join us for the spring semester’s first
<a href="https://physics.ucmerced.edu/slaam">Soft Living Active and Adaptive Matter (SLAAM)</a> seminar, to be given by <b>Dr. Andriy Goychuk
</b>(MIT) on <b>Monday, January 30,<span class="apple-converted-space"> </span></b>at <b>9am Pacific/11am Central/12 noon Eastern time</b>, with the title
<span class="apple-converted-space"><b><a href="https://physics.ucmerced.edu/sites/physics.ucmerced.edu/files/page/documents/andriy_goychuk_slaam.pdf">Folding patterns in heterogeneous active polymers</a>.</b></span><b><o:p></o:p></b></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;color:black"> <o:p></o:p></span></p>
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<span style="font-size:12.0pt;color:black"><a href="https://ucmerced.zoom.us/j/92693607475?pwd=TnI5dDhRRnYvejNZK2xNN0s4M0R5UT09" title="https://ucmerced.zoom.us/j/92693607475?pwd=TnI5dDhRRnYvejNZK2xNN0s4M0R5UT09"><span style="color:#0563C1">https://ucmerced.zoom.us/j/92693607475?pwd=TnI5dDhRRnYvejNZK2xNN0s4M0R5UT09</span></a><o:p></o:p></span></p>
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<span style="font-size:12.0pt;color:black">Zoom Meeting ID: 926 9360 7475 | Passcode: 223642<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;color:black"> <o:p></o:p></span></p>
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<span style="font-size:12.0pt;color:black">As usual, there will be a 15 min informal Q&A at the end of the hour. Graduate students will have an opportunity to interact with the speaker in an informal setting during the "Meet the speaker" timeslot just after
the talk. Please join if the time works for you. <o:p></o:p></span></p>
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<span style="font-size:12.0pt;color:black"> <o:p></o:p></span></p>
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<b><span style="font-size:12.0pt;color:black">Abstract:<o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:12.0pt;color:black">The folding of various biopolymers, ranging from proteins to chromosomes, into specific conformations is vital for cellular function. Longstanding research has elucidated basic principles of polymer
folding with equilibrium thermodynamics. However, thermodynamic constraints such as the fluctuation-dissipation relation can cease to hold in cells, whose organization and regulation involve active processes that provide local excitations. Here, by using analytical
theory, we investigate the response of a polymer’s conformation to excitations that are heterogeneous in magnitude, correlated along the polymer sequence or, at local hot spots, exhibit temporal patterns that can represent protein (un)binding cycles on chromatin.
We characterize how these different types of excitations can lead to specific folding patterns, by eliciting effective long-ranged attraction or repulsion. However, we also find that the folding patterns of an active polymer cannot be distinguished from a
passive polymer through structural data, such as contact probability maps, alone. Therefore, in closing, we discuss the different fluctuation properties, such as coherent motion, that can be expected to arise in such systems.<o:p></o:p></span></p>
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<b>About the speaker:</b><o:p></o:p></span></p>
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<span style="font-size:12.0pt;color:black">Dr. Andriy Goychuk is a postdoctoral associate at the Massachusetts Institute of Technology, where he will transition to an EMBO Long-Term postdoctoral fellowship in February 2023. He is broadly interested in applying
the methods and tools of theoretical biophysics, statistical mechanics and nonlinear dynamics to biological phenomena. Together with Professor Arup K. Chakraborty and Professor Mehran Kardar, he is currently investigating the formation of transcriptional condensates
on chromatin and the conformational dynamics of actively driven polymers.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;color:black">Dr. Goychuk has studied Physics at the Ludwig-Maximilians-University of Munich. Together with Professor Erwin Frey, he investigated different biological systems, ranging from the scale of proteins
to the scale of cell dynamics, which have mechanochemical couplings. His thesis was honored with the Arnold Sommerfeld PhD prize. <o:p></o:p></span></p>
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<span style="font-size:12.0pt;color:black"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;color:black"><o:p> </o:p></span></p>
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<span style="font-size:12.0pt;color:black">See you there!<span class="apple-converted-space"> </span><o:p></o:p></span></p>
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<span style="font-size:12.0pt;color:black"> <o:p></o:p></span></p>
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<span style="font-size:12.0pt;color:black">Best regards,<o:p></o:p></span></p>
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<span style="font-size:12.0pt;color:black">Dan Beller<o:p></o:p></span></p>
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<span style="font-size:12.0pt;color:black">on behalf of the SLAAM organizing team<o:p></o:p></span></p>
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<span style="font-size:12.0pt;color:black"> <o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="font-size:12.0pt;color:black">To join the SLAAM mailing list, please sign up <a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__docs.google.com_forms_d_e_1FAIpQLScTyzEuuE7TfrrapgP4tzN-5FoPSqbBhURUxa9-2Dzc8USnY1IPzA_viewform&d=DwMFAw&c=WO-RGvefibhHBZq3fL85hQ&r=6T170XR90Za4-nl9r1e8-WfEJbvH5g5hJbA9UumqfWQ&m=NK4EGo1VvrDiYSxdvOUJXgCkEAzTrQzNpQi-P59LZiKL_lMA3briJm9KQh9Y3suN&s=3hc1lEhiJwBLtMEr12Z9K5XtZaVlEfOZKYXGtXCjRDg&e=" title="https://urldefense.proofpoint.com/v2/url?u=https-3A__docs.google.com_forms_d_e_1FAIpQLScTyzEuuE7TfrrapgP4tzN-5FoPSqbBhURUxa9-2Dzc8USnY1IPzA_viewform&d=DwMFAw&c=WO-RGvefibhHBZq3fL85hQ&r=6T170XR90Za4-nl9r1e8-WfEJbvH5g5hJbA9UumqfWQ&m=NK4EGo1VvrDiYSxdvOUJXgCk"><span style="color:#0563C1">here</span></a>. If
you’re a postdoc interested in giving a SLAAM talk, we invite you to register your interest on that webform.
<o:p></o:p></span></i></p>
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<span style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt"><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">Daniel Beller<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">Assistant Professor<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">Department of Physics and Astronomy<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">Johns Hopkins University<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">pages.jh.edu/dbeller3<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.0pt;font-family:Helvetica;color:black">(he/him/his)</span><span style="font-size:12.0pt"><o:p></o:p></span></p>
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