[QSB-postdocs] QSB seminar tomorrow by Dr. Rajat Rohtagi from Stanford University

[Xuecai Ge]

Dear QSB community,


Please join us in the QSB seminar tomorrow by Dr. Rajat Rohatgi from Stanford University. Dr. Rohatgi is a pioneer in the study of cell signaling. He is the esteemed Pew scholar in the Biomedical Sciences and the awardee of NIH Director's New Innovator Award among many other awards and honors that he received.


The title for Dr. Rohatgi's talk:

Genetic Dissection of signaling pathways in cultured cells


Abstract:

A handful of signaling pathways mediate cell-cell communication during early development and are responsible for the vast diversity in tissue, organ and body morphology seen across animal phyla. These same pathways coordinate regenerative responses in adults and, when damaged, can cause birth defects, cancer and degeneration. One goal of my lab is to understand the molecular mechanisms that mediate signal transduction by these iconic and highly conserved developmental signaling systems. To discover new components and new mechanisms in two such pathways, the WNT and Hedgehog pathways, my lab has conducted a series of genome-wide screens in cultured cells using both CRISPR methods and insertional mutagenesis. These studies have identified new regulatory features at most levels of the pathway and also identified genes required selectively for oncogenic signaling. I will discuss our overall design strategy for these screens, as well as examples of novel signaling mechanisms.  The conceptual and methodological framework resulting from this work should enable the comprehensive understanding of other signaling systems.


Hope to see you all there!


Best,

Susan


------------------------

Xuecai (Susan) Ge, PhD

Assistant Professor

MCB | School of Natural Sciences

University of California, Merced

Cell: 617-470-6498

Lab: 209-228-3606

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