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<p>Hi Everyone,</p>
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<p>For those interested, we have a few spots available for lunch with Dr. Nathan Lanning PhD this Friday at 10.15am in COB2 290. Please let me know if you are interested and can make it. </p>
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<p>Thanks,</p>
<p>Simar</p>
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Title:<span style="font-size: 11.5pt; font-family: "Segoe UI", sans-serif; color: rgb(33, 33, 33);"></span></p>
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Surveying the Bioenergetic Landscape for New Therapeutic Targets<span style="font-size: 11.5pt; font-family: "Segoe UI", sans-serif; color: rgb(33, 33, 33);"></span></p>
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Abstract:<span style="font-size: 11.5pt; font-family: "Segoe UI", sans-serif; color: rgb(33, 33, 33);"></span></p>
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Mitochondrial dysfunction is associated with many pathologies including cancer, neurodegenerative diseases, cardiovascular disease, and mitochondrial diseases. However, in many cases, the distinct mechanisms by which mitochondrial dysfunction promotes these
diseases remain unknown, and up to 20% of the mitochondrial proteome remains functionally uncharacterized. We screened ~1,000 mitochondrial proteins for their contributions to maintaining cellular energy homeostasis, and identified a mitochondrial adenylate
kinase which significantly regulates ATP levels, AMPK/mTOR signaling, and cellular redox homeostasis.<span style="font-size: 11.5pt; font-family: "Segoe UI", sans-serif; color: rgb(33, 33, 33);"></span></p>
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Bio:<span style="font-size: 11.5pt; font-family: "Segoe UI", sans-serif; color: rgb(33, 33, 33);"></span></p>
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Nate Lanning studied signal transduction in cancer biology as an undergraduate. He then completed a Ph.D. in Cellular and Molecular Biology at the University of Michigan studying adaptor proteins and focal adhesion biology. Following this, he completed a postdoctoral
fellowship in Mitochondrial Systems Biology at the Van Andel Research Institute. In 2014, Nate established his independent research group as Assistant Professor in the Department of Biological Sciences at California State University, Los Angeles. The goal
of the Lanning lab is to map mitochondrial proteins and functions to normal and disease processes.</p>
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Simar J. Singh</p>
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PhD Candidate</p>
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Cancer Metabolism & Systems Biology Laboratory<br>
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Quantitative & Systems Biology Graduate Group</p>
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University of California, Merced</p>
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